5/13/97


Do any of the universities, companies, hospitals or research institutions

have any policies regarding the use of electron microscopy by pregant

employees? Is there any literature available on the topic?

Is the advice not to use EM at all during the 9 months, or maybe only

during critical periods of development?

In searching the archives I only found one reference on this topic.

Any help would appreciated.

Patrick Diehl

Materials Science Department

University of North Texas

diehl@unt.edu


Dear Patrick,

I have sheparded three pregnancies (users, not me) on my 200 kV TEM and I

found it a good way to get the instument monitored and thoroughly tested.

The last one wore a accumulation monitor at all times and found a curious

phenomenon: she accumulated more radiation when sitting at her desk, next to

the cinder-block wall in the next room, than when she was working at the TEM

at 200 kV. These instruments, when assembled and used properly and monitored

in case of leaks after maintenance, leak less x-rays than a TV. I believe

the regulations regarding radiation exposure are considered valid for

pregnant women.



Mary Mager

Electron Microscopist

Metals and Materials Eng., UBC

6350 Stores Rd.

Vancouver, B.C. V6T 1Z4

CANADA

tel:604-822-5648, fax:604-822-3619

e-mail: mager@unixg.ubc.ca


Dear Patrick,

I have got two healthy daughters (the youngest one is 10 weeks). During

the whole period of both my pregnancies I have worked with electron

microscopy (TEM, SEM, low vacuum SEM and environmental SEM).

Risoe National Laboratory is a former Atomic Energy Commission Research

Establishment, so we still have health physicists around. They were

consulted as soon as I realised that I was pregnant. The health

physicist measured the radiation level at all our TEMs and SEMs. Only

the background level of approx. 0.06 microSv/h was found. During the

my pregnancies I wore two badges that checked the radiation

continuosly. Nothing above background level was detected.

Charlotte C. Appel

Materials Research Department

Risoe National Laboratory

DK-4000 Roskilde DENMARK

c.c.appel@Risoe.DK


Radiation exposure should be limited to a fetus, particularly during the

first 3 months. The Nuclear Reg. Comm. limits this exposure to <500 mRem for the 9

months. This SHOULD be a huge value compared to any exposure from any EM

unless it is a HVTEM that is improperly setup (you must stay out of the chamber

when running <g>). A SEM running 30 kV. cannot produce any x-rays over 30 keV -

Most are well under. These relatively soft x-rays are (typically) completely

shielded by the column and chamber walls....Consult your manufacutrer for

detailed exposure rates. I think you will find that a cross country air

flight (or 9 months in Denver vs. a sea level city) will expose you to more radiation

than will 9 months in front of the EM.



Woody.N.White

Woody.N.White@mcdermott.com


Dear Patrick,



Everyone who uses radiation-producing equipment should be monitored.

We have ion-chamber dosimeters for occasional users and film badges for

people who are around the instrument every day. The limit for exposure for

pregnant women is 500 millirem over the course of the pregnancy, but this

amount should not happen in a short period. There is an unofficial limit

of 50 millirem per month. These numbers come from the experts in the NY

State Department of Health. For exposures to x-rays, rad and rem are equi-

valent, and 1 rad (Radiation Absorbed Dose) is 100 ergs per gram.

If you have no capability for monitoring users, the next best thing

is to use a detector, such as a Geiger counter or an ion chamber, to deter-

mine whether the radiation near the microscope is different from background.

If there is no difference between the radiation measured before the scope

is turned on and when it is cranked up fully, then you can be reasonably

sure there is no danger (assuming you have a detector which is sensitive

to the radiation your scope produces); however, this probably won't satisfy

any legal requirements.

William Tivol

tivol@wadsworth.org


egarding the questions of pregnancy and EM labs:



There is no danger from contemporary microscopes which are well

maintained and monitored. The problem exists with chemicals.

Cacodylate buffer if used in a laboratory eventually contaminates

bottles, hoods, etc., with fine arsenic dust. Then there is the lead

stain and the UA. Anyone pregnant should not be weighing out any

chemical containing heavy metals. Extreme care needs to be taken with

other noxious things such as glut, paraform, xylene, propylene, etc.

During my time in another lab, there occurred a chemical spill - the

holding tank backed up into the lab. A mixture of the above seeped up

through the floor drains. My coworker attempted to contain the spill

with a properly fitted mask. At the time she was 12 days pregnant. At

seven months she gave birth to a badly deformed baby which lived only for

an hour. After exhaustive investigation, it was decided that the uterine

fluid had been contaminated with heavy metals. The enormous quantity of

fluid gave her the appearance at seven months of a 10 months preganancy,

at least.

Anyone who is not protected by birth control and might be pregnant at any

time should not be weighing out questionable material, and should take

extreme care with being gloved, etc., at all times.

So long,

Hildy



HILDEGARD CROWLEY

hcrowley@odin.cair.du.edu


Dear Mary,

This is not so curious. The potassium-40, naturally occurring in

concrete is a well-known source of radiation. If the user had her desk in

Denver, there would have been an additional component from the greater

cosmic ray flux at high altitude.

William Tivol

tivol@wadsworth.org


I was wondering what most EM labs do for precautionary measures when someone in

the lab is pregnant. I have a colleague who is pregnant now, and she does not

do resin embedding. She does cut cured blocks,stain them with uranyl acetate

and lead citrate, and look at them on the TEM. Is this normal procedure in

other labs? Should she wear a mask when staining?

Linda Chicoine

Center for Cell Imaging

Yale University

New Haven, CT

Linda.Iadarola@quickmail.yale.edu


Dear Patrick,



I run a morphology core where a TEM is used every day. Last year when I

was pregnant, I called Health Physics who monitored the scope and me for a

period of time. There was absolutely no leakage fromm the column.

Although every scope is different, ours is brand new, you can always have

your environmental people come out and check for leaks. I believe them to

be safe - my son had all of his fingers and toes.



Cheri Owen

cowen@cmb.biosci.wayne.edu


[Return to Tips & Tricks Menu]