10/24/96


Greetings Friends, Can anyone help with a proceedure for CPD a

50um free floating section? It is brain tissue that has been fixed,

cryosectioned and returned to buffer. All wizardry is welcome at

this point !! Has anyone used Peldri II ? Would this be a

possibility? Thanks

Linda Fox lfox1@wpo.it.luc.edu


Linda;

CPD: cut the end off of a BEEM capsule, cut out the center of the

capsule's cap, cut off the cap of another BEEM capsule, cut out the center,

put plankton netting over the end of the capsule with the lid, put in

sections, close lid; dehydrate, standing open end up in a Wheaton 4 mL

vial, add EtOH to capsule, withdraw from vial outside of capsule; put on

cut-off lid with netting,

put in CPD & dry:

___/ \__

| /________________\ |

lid on 1st capsule ---> | | | | <-----lid, removed from 2nd

| | | |

| |________|_______| |

|__\ | /_|

\ | /<------plankton netting

|

BEEM

Peldri: fluorocarbon, not made anymore.

or: dehydrate as usual, and dry from HMDS (Hexamethyldisilizane).

Philip Oshel *all mail:*

Microscopy

University of Illinois Station A

Rm 74 Bevier Hall PO Box 5037

905 S. Goodwin Ave. Champaign, IL 61825-5037 USA

Urbana, IL 61801

(217) 244-3145

oshel@ux1.cso.uiuc.edu

(217) 355-1143 home


Have you tried Hexamethyldisilizane (HMDS for short). We have found

it more convient than Peldri and it gives similar to better results. There

are discussions about both which came across the list and I have archived

them at the web site listed at the end of this message. Click on the "Tips &

Tricks " button and look in the SEM section. Let me know if you cannot

access it and I will get it to you some other way

Scott Whittaker

sdw@biotech.ufl.edu


Linda & You:

Sorry Philip O. but Peldri II is available. (Ted Pella Inc & P&S)

Those compounds do nasty things to the Ozone layer but, I am afraid, my

motorcar alone could produce enough nitrous oxides to exceed the damage done

by all the Peldri in the world.

The technical issue is the fragillity and the preservation of the section

for this Peldri II would be may first choice.

Jim Darley

Probing & Structure

(Microscopy Supplies & Accessories)

PO Box 111, Thuringowa QLD 4817 Australia

Phone +61 77 740 370 Fax: +61 77 892 313

A great microscopy site http://www.ultra.net.au/~pns/


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