Cryo Electron Microscopy & Tomography at UF

Published: March 28th, 2013

Category: All News, Featured News, Proteomics and Mass Spectrometry

Symposium attendees listen as Jack Johnson discusses his research in cryo electron microscopy and tomography

The University of Florida ICBR Electron Microscopy and Bioimaging core laboratory, College of Medicine, and the Center for Structural Biology held an event on March 20 highlighting the expanded capabilities of electron microscopy and tomography through cryo freezing of samples now available at the university. The event hosted well known researchers whose research focuses on cryo technology at The Scripps Research Institute and Florida State University.  Jack Johnson, PhD and Beth Stroupe, PhD offered their expertise on the application of the technology and research that can be realized through these methods. 

The event featured a morning symposium with talks from Johnson and Stroupe, as well as our own UF researchers Byung-Ho Kang, PhD, ICBR, and Mavis Agbandje-McKenna, PhD, College of Medicine. A poster session was held in the Cancer and Genetics Research Complex atrium in coordination with lunch.  Posters featured research from many students and investigators from the Center for Structural Biology using cryo electron microscopy and tomography to model macromolecular structures.

A modeled Adeno Associated Virus complexed with
Fab component (part of an antibody), important in the pursuit of gene therapies

Following the poster session and lunch, attendees were guided on a tour of the ICBR Electron Microscopy and Bioimaging core laboratory, located in the Microbiology and Cell Science building.  They were given the chance to explore the new microscopes and ask questions of the core laboratory staff.

The combination of freezing samples and the ability to model large molecular assemblies in their physiological state and at extreme resolution can provide insight into biological components of many types.  The technology can capture and help researchers build models of viruses, bacteria, cellular components, and other tiny molecular structures.

If you are considering utilizing the Electron Microscopy and Bioimaging core laboratory for your research needs, or simply have questions on how this technology can aid in your investigations, please contact us at ICBR-ElectronMicroscopy@ad.ufl.edu.

 

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