Phase Genomics Seminar
March 5 @ 12:00 PM - 1:00 PM
Join us on March 5th for a seminar with ICBR Bioinformatics and Phase Genomics in CGRC 133
Event Title: How Hi-C is transforming genome and metagenome assembly
Event Description: Chromosome conformation capture methods like Hi-C measure the 3D organization of DNA in vivo using a combination of crosslinking, proximity-ligation, and paired-end sequencing.
Because this method captures genomic contiguity on intact chromosomes, the resultant information can be used to generate end-to-end chromosome-scale scaffolds for large genomes. Since Hi-C junctions form within intact cells, any sequences interacting by Hi-C must have originated from the same species/strain in a mixed population, enabling metagenomic deconvolution.
Capturing genomic proximity information in vivo removes several major obstacles in genome and metagenome assembly, improving the quality and efficiency of genome discovery efforts.