Topic: ATP-dependent chromatin remodeling and the dynamics of histone variant H2A.Z
Speaker: Dr. Carl Wu, NIH Scientist Emeritus, Laboratory of Biochemistry & Molecular Biology, NCI; Senior Fellow, HHMI; Member, Natl. Acad. Sci
Biography: Carl Wu is a senior fellow at the Janelia Farm Research Campus of the Howard Hughes Medical Institute in Ashburn, Virginia. He studies the molecular architecture of chromosomes and the role of chromatin structure in gene transcription – areas that are central to the understanding how genomic information is programmed for selective expression in the development of the organism. Wu received his B.S. from St. mary’s College of California and Ph.D. in biology from Harvard University, where he began his study of chromatin organization under Sarah Elgin. After finding that the chromatin of gene promoters is remodeled as DNase I hypersensitive sites while Junior Fellow at Harvard under Wally Gilbert, Wu moved to the National Cancer Insitiute where he investigated biochemical mechanisms of chromatin remodeling for three decades and served as Chief of the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research. His laboratory is best known for the characterization of the Heat Shock Transcription Factor, master regulator of the cellular heat stress response, and of ATP-dependent chromatin remodeling enzymes. At Janelia Far, Wu is extending his work in new directions, to developing fresh analytical methods for the epigenome, and imaging local chromatin dynamics and large-scale chromatin folding in live cells. Wu is an elected member of the National Academy of Sciences, the Institute of medicine, the American Academy of Arts and Sciences, the Academia Sinica, and the European Molecular Biology Organization.
This seminar is co-sponsored with the UF College of Medicine.